A generally used medication for male pattern baldness, finasteride, may have serious risks to mental health, according to new research from Israel. The study, led by Dr. Mayer Brezis at Hadassah-Hebrew University Medical Center, suggests that users of the drug are facing a significantly higher probability of mood disorders, depression and even suicidal thoughts compared to those who do not take it. While Finasteride, also known under its brand Propecia, has been prescribed since the 1990s to treat hair loss, new evidence indicates that the potential psychological side effects have been underestimated for several years. Experts are now urging supervisory authorities to reconsider the safety of the drug.
Hair loss treatment and mental health risks
Animal studies have previously linked finasteride to prolonged brain inflammation and changes in the hippocampus, a brain region necessary for memory, learning and emotional regulation. The FDA recognized depression as a potential side effect in 2011 and added suicidal thoughts and behavior to the label in 2022. However, internal FDA documents revealed by Brezis indicate that concerns about suicide risk were increased as early as 2010, even if the agency reportedly rejected these warnings without revealing the rational.Brezis highlights a major problem with pharmacovigilance and claims that under -reporting and insufficient safety studies have masked the actual fine fee. While official FDA records noted 18 suicide linked to the drug in 2011, global estimates may be much higher, given its widespread use. Critics also point to Merck, the original manufacturer of the drug, so as not to conduct thorough database analyzes and to insufficiently investigate potential risks to mental health.
Prompts regulatory measures
Given these results, Brezis advocates a temporary suspension of finasteride for cosmetic use until a complete safety evaluation is carried out. He also urges the FDA that mandate studies after approval for all drugs with potential psychiatric side effects and to ensure that suicide examinations systematically include patient medicines.For those who are concerned about finasteride, the FDA-approved topical minoxidil remains a safer alternative for androgenetic alopecia. While traditional minoxidil has limited Hudabsorption, new research indicates combining it with Stevioside, a natural compound derived from the Stevia plant, can improve the delivery to hair follicles and stimulate regrowth. Experts note that treatment is most effective in the early stages of hair loss, and interruptions will usually lead to gradual return of the results.
Awareness and informed choices
The study emphasizes the importance of understanding the potential side effects of generally used medicines. Patients who experience mood changes when using hair loss treatments should immediately consult health care providers. As evidence, both supervisory authorities, doctors and patients must weigh cosmetic benefits against potentially serious mental health risks.
